Fabrication of alginate microparticles by microfluidic device for vorinostat anti-cancer agent delivery
298 viewsDOI:
https://doi.org/10.54939/1859-1043.j.mst.84.2022.86-92Keywords:
Anti-cancer drugs; Calcium alginate; Microparticle; Microfluidic device; Vorinostat.Abstract
Microfluidic systems are an emerging technology for the fabrication of microparticles for drug delivery systems. This study investigated the vorinostat carrying capacity of alginate microparticles generated by the microfluidic device. The efficiency of the microcapsules were examined by scanning electron microscopy, SEM, EDS-Mapping showing the change on the microcapsules surface compared with the original microparticles. Drug-excipient interaction studies using FT-IR spectroscopy showed no change in the characteristic peaks of the drug. The encapsulation efficiency is 58.8%. Overall, the present investigation corroborated successful development of microparticles of vornostat as an effective and cost-effective approach for delivery of vornostat.
References
[1]. Li, Chong, et al. "Recent progress in drug delivery." Acta Pharmaceutica Sinica B 9.6: 1145-1162, (2019). DOI: https://doi.org/10.1016/j.apsb.2019.08.003
[2]. Trần Thị Luyến và Ngô Đăng Nghĩa, "Nghiên cứu sản xuất sodium alginate theo phương pháp xử lý CaCl2 0.1%", Tập san KHCN – Trương Đại học Thủy sản Nha trang, (1999).
[3]. Tomaro-Duchesneau, Catherine, et al. "Microencapsulation for the therapeutic delivery of drugs, live mammalian and bacterial cells, and other biopharmaceutics: current status and future directions." Journal of pharmaceutics (2013).
[4]. Agüero, Lissette, et al. "Alginate microparticles as oral colon drug delivery device: A review." Carbohydrate polymers 168: 32-43, (2017).
[5]. Lengyel, Miléna, et al. "Microparticles, microspheres, and microcapsules for advanced drug delivery." Scientia Pharmaceutica 87.3: 20, (2019).
[6]. Rashid, Muzamil, et al. "Microparticles as controlled drug delivery carrier for the treatment of ulcerative colitis: A brief review." Saudi Pharmaceutical Journal 24.4: 458-472, (2016). DOI: https://doi.org/10.1016/j.jsps.2014.10.001
[7]. Tomaro-Duchesneau, Catherine, et al. "Microencapsulation for the therapeutic delivery of drugs, live mammalian and bacterial cells, and other biopharmaceutics: current status and future directions." Journal of pharmaceutics (2013). DOI: https://doi.org/10.1155/2013/103527
[8]. Agüero, Lissette, et al. "Alginate microparticles as oral colon drug delivery device: A review." Carbohydrate polymers 168: 32-43, (2017). DOI: https://doi.org/10.1016/j.carbpol.2017.03.033
[9]. Lengyel, Miléna, et al. "Microparticles, microspheres, and microcapsules for advanced drug delivery." Scientia Pharmaceutica 87.3: 20, (2019). DOI: https://doi.org/10.3390/scipharm87030020
[10]. Mann, Bhupinder S., et al. "FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma." The oncologist 12.10: 1247-1252, (2007). DOI: https://doi.org/10.1634/theoncologist.12-10-1247
[11]. Bubna, Aditya Kumar. "Vorinostat—an overview." Indian journal of dermatology 60.4 (2015): 419. DOI: https://doi.org/10.4103/0019-5154.160511
[12]. Huang, Keng-Shiang, et al. "Calcium alginate microcapsule generation on a microfluidic system fabricated using the optical disk process." Journal of Micromechanics and Microengineering 17.8: 1428, (2007). DOI: https://doi.org/10.1088/0960-1317/17/8/003
[13]. White House Station, NJ: Merck and Co; 2006. “Zolinza (vorinostat)” Full Prescribing Information.
[14]. Grant, Steven, Chris Easley, and Peter Kirkpatrick. "Vorinostat." Nature reviews Drug discovery 6.1: 21-23, (2007). DOI: https://doi.org/10.1038/nrd2227
[15]. Mohamed, Elham A., et al., "Vorinostat with sustained exposure and high solubility in poly(ethylene glycol)-b-poly(dl-lactic acid) micelle nanocarriers: Characterization and effects on pharmacokinetics in rat serum and urine", Journal of Pharmaceutical Sciences. 101(10), pp. 3787-3798, (2012). DOI: https://doi.org/10.1002/jps.23265
[16]. Vijayaraghavalu, Sivakumar and Labhasetwar, Vinod, "Nanogel-mediated delivery of a cocktail of epigenetic drugs plus doxorubicin overcomes drug resistance in breast cancer cells", Drug Delivery and Translational Research. 8(5), pp. 1289-1299, (2018). DOI: https://doi.org/10.1007/s13346-018-0556-y
[17]. Dang, T. D., and S. W. Joo. "Preparation of tadpole-shaped calcium alginate microparticles with sphericity control." Colloids and Surfaces B: Biointerfaces 102: 766-771, (2013). DOI: https://doi.org/10.1016/j.colsurfb.2012.09.016
