STUDY ON THE SYNTHESIS OF AMINOALCOHOL VIA REACTION BETWEEN ALDEHYDE AND IMINE BY SAMARIUM (II) IODIDE CATALYST
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Samarium (II) iodide; Aminoalcohol; Pinacol coupling; Imine.Abstract
Samarium (II) iodide (SmI2) has become one of the common, effective catalysts for coupling reactions between carbonyl compounds to form 1,2-diol by initiating free radical formation. In this paper, we present the results of studying the role of SmI2 catalyst on the aza-pinacol coupling reaction between aldehyde and imine under different mole ratios of SmI2, temperature and solvent conditions. The results showed that, in the THF solvent, at -78 °C, with 2.0 mole equivalent of the SmI2 catalyst, the reaction of pinacol coupling produces 1,2-aminoalcohols with efficiency of up to 91% yield and limited 1,2-diol by product.
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