Heparin - Pluronic F127 nanogel with optimal component ratio for drug delivery applications

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Authors

  • Nguyen Thi Huong (Corresponding Author) Institute of Chemistry and Materials, Academy of Military Science and Technology
  • Nguyen Ngoc Son Institute of Chemistry and Materials, Academy of Military Science and Technology
  • Trinh Dac Hoanh Institute of Chemistry and Materials, Academy of Military Science and Technology
  • Doan Van Phuc Institute of Chemistry and Materials, Academy of Military Science and Technology
  • Dam Thi Vui Thai Nguyen University of Science
  • Nguyen Thi Hai Yen Thai Nguyen University of Science
  • Pham The Chinh Thai Nguyen University of Science

DOI:

https://doi.org/10.54939/1859-1043.j.mst.88.2023.58-65

Keywords:

Heparin; Nanogel; Platin drug; Pluronic F127; Poor water-soluble drug.

Abstract

This study aimed to synthesize a nanogel system based copolymers of Heparin (Hep) and Pluronic F127 (F127) with optimal Hep:F127 ratio for delivering poor water soluble drug and Platinum-based drugss. Firstly, Hep-F127 conjugates were formed via disulfide bridges of cystamine molecules. The obtained Hep-F127 systems were then proved and characterized using Proton nuclear magnetic resonance (1H-NMR), Dynamic Light Scattering (DLS)) methods. Cisplatin (CPT) was used as the Pt drug model, meanwhile Paclitaxel (PTX) was used as poor water-soluble drug model. The encapsulation ability for CPT and PTX was investigated and compared to choose the optimal Hep-F127 ratio. This Hep-F127 nanogel system is expected to be a good carrier for delivering drugs with different properties.

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Published

25-06-2023

How to Cite

Nguyen Thi, D. H., Nguyen Ngoc Son, Trinh Dac Hoanh, Doan Van Phuc, Dam Thi Vui, Nguyen Thi Hai Yen, and Pham The Chinh. “Heparin - Pluronic F127 Nanogel With Optimal Component Ratio for Drug Delivery Applications”. Journal of Military Science and Technology, vol. 88, no. 88, June 2023, pp. 58-65, doi:10.54939/1859-1043.j.mst.88.2023.58-65.

Issue

Vol. 88 (2023)

Section

Research Articles