Heparin - Pluronic F127 Nanogel với tỷ lệ thành phần tối ưu cho các ứng dụng mang thuốc
184 lượt xemDOI:
https://doi.org/10.54939/1859-1043.j.mst.88.2023.58-65Từ khóa:
Nanogel; Cisplatin; Pluronic F127; Paclitaxel.Tóm tắt
Nghiên cứu tổng hợp copolyme trên cơ sở Heparin (Hep) và Pluronic F127 (F127) với tỷ lệ Hep:F127 tối ưu để nang hoá hai hệ thuốc Paclitaxel và cisplatin. Sự tạo thành copolyme của liên hợp Hep-F127 được hình thành thông qua các cầu nối disulfide của các phân tử cystamine. Các hệ Hep-F127 thu được đã được nghiên cứu đặc trưng cấu trúc bằng phương pháp cộng hưởng từ hạt nhân Proton (1H-NMR), thế Zeta và tán xạ ánh sáng động (DLS). Dược chất Cisplatin (CPT) được sử dụng cho mô hình nang hoá dược chất tan trong nước, trong khi Paclitaxel (PTX) được sử dụng cho mô hình nang hoá thuốc kém tan trong nước. Khả năng nang hoá CPT và PTX của hệ nanogel đã được khảo sát để lựa chọn tỷ lệ Hep-F127 tối ưu trong từng mô hình.
Tài liệu tham khảo
[1]. Cerqueira, M.A., et al., "Structural and thermal characterization of galactomannans from non-conventional sources". Carbohydrate polymers, 83(1): p. 179-185, (2011). DOI: https://doi.org/10.1016/j.carbpol.2010.07.036
[2]. Yao, Y., et al., "Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance". Frontiers in molecular biosciences, 7: p. 193. (2020). DOI: https://doi.org/10.3389/fmolb.2020.00193
[3]. Hassanzadeh, P., F. Atyabi, and R. Dinarvand, "The significance of artificial intelligence in drug delivery system design". Advanced drug delivery reviews, 151: p. 169-190. (2019). DOI: https://doi.org/10.1016/j.addr.2019.05.001
[4]. Jarak, I., et al., "Pluronic-based nanovehicles: Recent advances in anticancer therapeutic applications". European Journal of Medicinal Chemistry, 206: p. 112526. (2020). DOI: https://doi.org/10.1016/j.ejmech.2020.112526
[5]. Pitto-Barry, A. and N.P. Barry, "Pluronic® block-copolymers in medicine: from chemical and biological versatility to rationalisation and clinical advances". Polymer Chemistry, 5(10): p. 3291-3297. (2014). DOI: https://doi.org/10.1039/C4PY00039K
[6]. Nguyen, T.T.C., et al., "Highly lipophilic pluronics-conjugated polyamidoamine dendrimer nanocarriers as potential delivery system for hydrophobic drugs". Materials Science and Engineering: C, 70: p. 992-999. (2017). DOI: https://doi.org/10.1016/j.msec.2016.03.073
[7]. Xu, C., B. Wang, and S. Sun, "Dumbbell-like Au− Fe3O4 nanoparticles for target-specific platin delivery". Journal of the American Chemical Society, 131(12): p. 4216-4217. (2009). DOI: https://doi.org/10.1021/ja900790v
[8]. Park, S.S., et al., "Functionalised mesoporous silica nanoparticles with excellent cytotoxicity against various cancer cells for pH-responsive and controlled drug delivery". Materials & design, 184: p. 108187. (2019). DOI: https://doi.org/10.1016/j.matdes.2019.108187
[9]. Kemp, M.M. and R.J. Linhardt, "Heparin‐based nanoparticles". Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2(1): p. 77-87. (2010). DOI: https://doi.org/10.1002/wnan.68
[10]. Argyo, C., et al., "Heparin‐Coated Colloidal Mesoporous Silica Nanoparticles Efficiently Bind to Antithrombin as an Anticoagulant Drug‐Delivery System. Chemistry"–A European Journal, 18(2): p. 428-432. (2012). DOI: https://doi.org/10.1002/chem.201102926
[11]. Peng, X.-H., et al., "Targeted delivery of cisplatin to lung cancer using ScFvEGFR-heparin-cisplatin nanoparticles". Acs Nano, 5(12): p. 9480-9493. (2011). DOI: https://doi.org/10.1021/nn202410f
[12]. Nguyen, N.T., et al., "Synergic activity against MCF-7 breast cancer cell growth of nanocurcumin-encapsulated and cisplatin-complexed nanogels". Molecules, 23(12): p. 3347. (2018). DOI: https://doi.org/10.3390/molecules23123347
[13]. Truong-Thi, N.-H., et al., "pH-Responsive Delivery of Platinum-based Drugs through the Surface Modification of Heparin on Mesoporous Silica Nanoparticles". European Polymer Journal, p. 111818. (2023). DOI: https://doi.org/10.1016/j.eurpolymj.2023.111818
[14]. Golla, E.D. and G.H. Ayres, "Spectrophotometric determination of platinum with o-phenylenediamine". Talanta, 20(2): p. 199-210. (1973). DOI: https://doi.org/10.1016/0039-9140(73)80267-X
[15]. Trang Le, N.T., et al., "Preparation of liposomal nanocarrier by extruder to enhance tumor accumulation of paclitaxel". Journal of Bioactive and Compatible Polymers, 37(1): p. 3-16. (2022). DOI: https://doi.org/10.1177/08839115211053926
[16]. Vu, M.T., et al., "Development and characterization of soy lecithin liposome as potential drug carrier systems for codelivery of letrozole and paclitaxel". Journal of Nanomaterials, p. 1-9. (2020). DOI: https://doi.org/10.1155/2020/8896455
[17]. Vu, M.T., et al., "Development, characterization and in vitro evaluation of paclitaxel and anastrozole Co-loaded liposome". Processes, 8(9): p. 1110. (2020). DOI: https://doi.org/10.3390/pr8091110
[18]. Le, N.T.T., et al., "Methoxy polyethylene glycol–cholesterol modified soy lecithin liposomes for poorly water‐soluble anticancer drug delivery". Journal of Applied Polymer Science, 138(7): p. 49858. (2021). DOI: https://doi.org/10.1002/app.49858
[19]. Shaikhullina, M., et al., "NMR relaxation and self-diffusion in aqueous micellar gels of pluronic F-127". Journal of Molecular Liquids, 306: p. 112898. (2020). DOI: https://doi.org/10.1016/j.molliq.2020.112898
[20]. Choi, J.H., et al., "Self-assembled nanogel of pluronic-conjugated heparin as a versatile drug nanocarrier". Macromolecular research, 19(2): p. 180-188. (2011). DOI: https://doi.org/10.1007/s13233-011-0214-4
[21]. Pomin, V.H., "1H and 15N NMR analyses on heparin, heparan sulfates and related monosaccharides concerning the chemical exchange regime of the N-sulfo-glucosamine sulfamate proton". Pharmaceuticals, 9(3): p. 58. (2016). DOI: https://doi.org/10.3390/ph9030058
[22]. Nguyen, D.H., et al., "Targeting ligand-functionalized and redox-sensitive heparin-Pluronic nanogels for intracellular protein delivery". Biomedical Materials, 6(5): p. 055004. (2011). DOI: https://doi.org/10.1088/1748-6041/6/5/055004
[23]. Mitchell, M.J., et al., "Engineering precision nanoparticles for drug delivery". Nature Reviews Drug Discovery, 20(2): p. 101-124. (2021). DOI: https://doi.org/10.1038/s41573-020-0090-8
[24]. Chen, F., et al., "Engineering of hollow mesoporous silica nanoparticles for remarkably enhanced tumor active targeting efficacy". Scientific reports, 4(1): p. 1-10. (2014). DOI: https://doi.org/10.1038/srep05080
