Synthesis and characterization of F127-Glu@ZnO nanogel material for cisplatin drug delivery application
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https://doi.org/10.54939/1859-1043.j.mst.FEE.2024.237-242Keywords:
Zinc oxide nanoparticles (ZnO NPs); Glutamic acid; Cisplatin; Drug delivery system.Abstract
A novel F127-Glu@ZnO nanogel was synthesized for cisplatin delivery by functionalizing ZnO nanoparticles with L-glutamic acid (Glu) and grafting Pluronic onto Glu via urethane linkages. FT-IR and ¹H-NMR confirmed successful synthesis, while TEM characterized morphology. The nanogel exhibited pH-responsive drug release, accelerating cisplatin release in acidic environments. This suggests its potential as a smart drug delivery system for improving therapeutic efficacy and reducing side effects in cancer treatment.
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