FINITE SIMULATIONS OF MICRO-PARTICLE SUPPORTING FOR SINGLE CELL TRAPPING IN MICROFLUIDIC SYSTEM
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Microfluidic; Single cell trapping; Finite element simulation.Abstract
Finite element method (FEM) is the most widely used approach in the simulation of micro-nano devices before actual fabrication. Using simulation software, 2D and 3D structures of the device are designed, meshed, and then simulated to optimize their parameters. In this work, we modeled and simulated the hydrodynamic trapping of micro-particle (μP) representing for single-cell in the microfluidic system. Besides, the interaction between μP and fluid, the effect of flow velocity, and the pressure field variation for increasing the trapping efficiency were investigated. Besides, a fully understanding the behavior of micro-particle during the trapping process is exhibited. Based on the achieved results, the optimization of the design will be adjusted as a pre-step before being used for fabrication and experiment. The simulation results are valuable for designing and fabricating the microfluidic platform for single-cell research.
