Green synthesis of selenium nanoparticles using aloe leaf extract and evaluation of acute toxicity of materials
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https://doi.org/10.54939/1859-1043.j.mst.99.2024.69-77Keywords:
Selenium nanoparticles; Aloe leaf extract; Acute toxicity.Abstract
The element selenium (Se) is of great importance in many fields, such as physics, chemistry, and biology. Selenium is also an important trace element, which has a great influence on biological systems due to its antioxidant, anticancer and antiviral activities. Selenium deficiency can lead to a number of serious diseases such as cancer, cardiovascular disease, immune disorders, or cause immunosuppression. Selenium nanoparticles are much more biologically active than other forms of selenium that exist in the form of inorganic salts or in organic compounds. In this paper, selenium nanoparticles are synthesized using a green method using aloe vera leaf extract which acts as a reducing agent and dispersion stabilizer. The properties of the post-synthetic materials analyzed by UV-vis spectroscopy, selected area diffraction (SAED), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS) showed that the synthesized selenium nanoparticles were in the range of 30 - 70 nm. The results of the assessment of acute toxicity in rats showed a lethal concentration (50% death of mice) of 10,374 mg/kg.
References
[1]. Zhang JS, Gao XY, Zhang LD, Bao YP. “Biological effect of nano red elemental selenium”. Biofactors;15(1): 27–38, (2001). DOI: https://doi.org/10.1002/biof.5520150103
[2]. Aribi M, Meziane W, Habi S, Boulatika Y, Marchandin H, Aymeric JL. “Macrophage bactericidal activities against staphylococcus sereus are enhanced In vivo by selenium supplementation in a dose- dependent manner”. PLoS One; 10 (9): e0135515, (2015). DOI: https://doi.org/10.1371/journal.pone.0135515
[3]. Kumar S, Tomar MS, Acharya A. “Carboxylic group-induced synthesis and char- acterization of selenium nanoparticles and its anti-tumor potential on Dalton's lymphoma cells”. Colloids Surf B: Biointerfaces; 126: 546-552, (2015). DOI: https://doi.org/10.1016/j.colsurfb.2015.01.009
[4]. Kumar A, Prasad S. “Role of nano-selenium in health and environment”. J Biotechnol; 325: 152-163, (2021). DOI: https://doi.org/10.1016/j.jbiotec.2020.11.004
[5]. Jing Gao et al. “Daily selenium intake in a moderate selenium deficiency area of Suzhou, China”. Food Chemistry. Volume 126, Issue 3, Pages 1088-1093, (2011). DOI: https://doi.org/10.1016/j.foodchem.2010.11.137
[6]. C. Ramamurthy et al. “Green synthesis and characterization of selenium nanoparticles and its augmented cytotoxicity with doxorubicin on cancer cells”. Bioprocess Biosyst. Eng. vol. 36, no. 8, pp. 1131-1139, (2013). DOI: https://doi.org/10.1007/s00449-012-0867-1
[7]. Khanna P et al. “Selenium nanoparticles: a review on synthesis and biomedical applications”. Mater Adv.; 3: 1415-1431, (2022).
[8]. Wang H, Zhang J, Yu H. “Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on sele- noenzymes: comparison with selenomethionine in mice”. Free Radic Biol Med; 42(10): 1524-1533, (2007). DOI: https://doi.org/10.1016/j.freeradbiomed.2007.02.013
[9]. Sieber F et al. “Elemental selenium generated by the photobleaching of seleno-merocyanine photosensitizers forms conjugates with serum macro-molecules that are toxic to tumor cells”, Phosphorus Sulfur Silicon Relat. Elem.; 180: 647–657, (2005). DOI: https://doi.org/10.1080/10426500590907200
[10]. Saini D, Fazil M, Ali MM, Baboota S, Ameeduzzafar A, Ali J. “Formulation, development and optimization of raloxifene-loaded chitosan nanoparticles for treatment of osteoporosis”. Drug Deliv.; 22(6):823-836, (2015). DOI: https://doi.org/10.3109/10717544.2014.900153
[11]. Yanhua Huang, Qingli Chen, Hai Zeng, Chen Yang, Guan Wang, Li Zhou. “A Review of Selenium (Se) Nanoparticles: From Synthesis to Applications”. Particle & Particle Systems Characterization Volume 40, Issue 11, (2023). DOI: https://doi.org/10.1002/ppsc.202300098
[12]. Neha Bisht, Priyanka Phalswal and Pawan K. Khanna. “Selenium nanoparticles: a review on synthesis and biomedical applications”. Materials Advances, 3, 1415–1431, (2022). DOI: https://doi.org/10.1039/D1MA00639H
[13]. Phuong Thi Mai Nguyen et al. “Green synthesis of selenium nanoparticles with augmented biological activity using Smilax glabra Roxb extract combined with electrochemical plasma”. Nano-Structures & Nano-Objects. Volume 38, 101185, (2024). DOI: https://doi.org/10.1016/j.nanoso.2024.101185
[14]. Marta Sánchez, Elena González-Burgos, Irene Iglesias, and M. Pilar Gómez-Serranillos. “Pharmacological Update Properties of Aloe Vera and its Major Active Constituents”. Molecules; 25(6): 1324, (2020). DOI: https://doi.org/10.3390/molecules25061324
[15]. Borna Fardsadegh and Hoda Jafarizadeh-Malmiri. “Aloe vera leaf extract mediated green synthesis of selenium nanoparticles and assessment of their In vitro antimicrobial activity against spoilage fungi and pathogenic bacteria strains”. Green Process Synth.; 8: 399-407, (2019). DOI: https://doi.org/10.1515/gps-2019-0007
[16]. Mustafa H.N, Nnas S.mohammed. “Synthesis of Silver Nanoparticles by Using Aloe Vera and Bio Application”. Journal of Nanostructures. Volume 13, Issue 1, Pages 59-65, (2023).
[17]. Prashant J. Burange et al. “Synthesis of silver nanoparticles by using Aloe vera and Thuja orientalis leaves extract and their biological activity: a comprehensive review”. Bull Natl Res Cent. 45, 181 (2021). DOI: https://doi.org/10.1186/s42269-021-00639-2
[18]. José A. Hernández-Díaz et al. “Antibacterial Activity of Biosynthesized Selenium Nanoparticles Using Extracts of Calendula officinalis against Potentially Clinical Bacterial Strains”. Molecules, 26, 5929, (2021). DOI: https://doi.org/10.3390/molecules26195929
[19]. Nahid Shahabadi, Saba Zendehcheshm, Fatemeh Khademi. “Selenium nanoparticles: Synthesis, in-vitro cytotoxicity, antioxidant activity and interaction studies with ct-DNA and HSA, HHb and Cyt c serum proteins”. Biotechnology Reports. Volume 30, e00615, (2021). DOI: https://doi.org/10.1016/j.btre.2021.e00615
[20]. M. Salah, Nesreen A. S. Elkabbany & Abir M. Partila. Salah, M., Elkabbany, N.A.S. & Partila, A.M. “Evaluation of the cytotoxicity and antibacterial activity of nano-selenium prepared via gamma irradiation against cancer cell lines and bacterial species”. Sci Rep. 14, 20523 (2024). DOI: https://doi.org/10.1038/s41598-024-69730-8
[21]. Muhammad Aamir Ramzan Siddique et al. “Ascorbic acid-mediated selenium nanoparticles as potential antihyperuricemic, antioxidant, anticoagulant, and thrombolytic agents”. Green Processing and Synthesi; 13: 20230158, (2024). DOI: https://doi.org/10.1515/gps-2023-0158
[22]. M. Shakibaie, A. R. Shahverdi, M. A. Faramarzi, G. R. Hassanzadeh, H. R. Rahimi, and O. Sabzevari. “Acute and subacute toxicity of novel biogenic selenium nanoparticles in mice”. Pharm. Biol. vol. 51, no. 1, pp. 58-63, (2013). DOI: https://doi.org/10.3109/13880209.2012.710241
