Structures of phenolic compounds isolated from Eupatorium adenophorum



  • To Phuong Linh Institute of New Technology, Academy of Military Science and Technology
  • Vu Ngoc Toan Institute of New Technology, Academy of Military Science and Technology
  • Dong Ngoc Phuc Faculty of Chemistry, VNU University of Science
  • Tran Xuan Truc Faculty of Chemistry, VNU University of Science
  • Vu Minh Trang VNU University of Education
  • Tran Thi Thu Thuy Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
  • Phan Minh Giang (Corresponding Author) Faculty of Chemistry, VNU University of Science



Eupatorium adenophorum; Thymol; Phenolic acid; Flavonol; Glucoside.


 Nowadays, phytochemical profiles of plants are the basis for the evaluation of their biological activities and ecological impact on environment and other living species. Chromatographic separation and NMR structural analysis were used in this paper to study the occurrence of six phenolic compounds in water fraction from the leaves of Eupatorium adenophorum Spreng. Structures of the compounds were identified as 4-hydroxybenzoic acid, methyl 3,4-dihydroxybenzoate, isovanillic acid, 5-O-glucopyranosylthymoquinol, 2-O-b-D-glucopyranosylcinnamic acid, and quercetagetin 7-O-b-D-glucopyranoside.


[1]. P.-Y. Liu, D. Liu, W.-H. Li, T. Zhao, F. Sauriol, Y.-C. Gu, Q.-W. Shi, M.-L. Zhang “Chemical constituents of plants from the genus Eupatorium (1904-2014)”, Chemistry & Biodiversity, Vol. 12 (2015), pp. 1481-1515. DOI:

[2]. M.G. Phan, V.M. Trang, D.T.V. Huong, S. Kawakami, H. Otsuka “Thymol derivatives from Eupatorium fortunei”, Records of Natural Products, Vol. 13, No. 5 (2019), pp. 434-439. DOI:

[3]. P.M. Giang, N.T. Thuy, D.H. Nam, T.T.H. Thu, D.T.V. Huong “Phenolic compounds, terpenoids, and sterols from Eupatorium japonicum Thunb. in Vietnam”, Tạp chí Hóa học, Vol. 57, No. 2E1,2 (2019), pp. 243-247.

[4]. D.T.V. Huong, P.M. Giang, V.M. Trang “Coumarins and polar constituents from Eupatorium triplinerve and evaluation of their -glucosidase inhibitory activity”, Journal of Chemistry, Vol. 2020 (2020), Article ID 8945063, DOI:

[5]. M.G. Phan, T.T. Do, T.N. Nguyen, T.V.H. Do, N.P. Dong, M.T. Vu “Chemical constituents of Eupatorium japonicum and anti-inflammatory, cytotoxic, and apoptotic activities of eupatoriopicrin on cancer stem cells”, Evidence-Based Complementary and Alternative Medicine, Vol. 2021 (2021), Article ID 6610347, DOI:

[6]. Q.P. Ma, C.-R. Cheng, X.-F. Li, X.-Y. Liang, J. Ding “Chemistry, pharmacological activity and analysis of Ageratina adenophora”, Asian Journal of Chemistry, Vol. 27, No. 12 (2015), pp. 4311-4316. DOI:

[7]. X. Zhao, G.-W. Zheng, X.-M. Niu, W.-Q. Li, F.-S. Wang, S.-H. Li “Terpenes from Eupatorium adenophorum and their allelopathic effects on Arabidopsis seeds germination”, Journal of Agricultural and Food Chemistry, Vol. 57 (2009), pp. 478-482. DOI:

[8]. N.P. Neupane, A.K. Karn, I.H. Mukeri, P. Pathak, P. Kumar, S. Singh, I.A. Qureshi, T. Jha, A. Verma “Molecular dynamics analysis of phytochemicals from Ageratina adenophora against COVID-19 main protease (Mpro) and human angiotensin-converting enzyme 2 (ACE2)”, Biocatalysis and Agricultural Biotechnology, Vol. 32 (2021), 101924. DOI:

[9]. A. Kundu, S. Saha, V. Ahluwalia, S. Walia “Plant growth inhibitory terpenes from Eupatorium adenophorum leaves”, Journal of Applied Botany and Food Quality, Vol. 86 (2013), pp. 33-36.

[10]. Azizuddin, T. Makhmoor, M. I. Choudhary “Radical scavenging potential of compounds isolated from Vitex agnus-castus”, Turkish Journal of Chemistry, Vol. 34 (2010), pp. 119-126. DOI:

[11]. N. T. T. Ha, P. V. Cuong, N. T. Tra, L. T. T. Anh, B. T. Cham, N. T. Son “Chemical constituents from methanolic extract of Garcinia mackeaniana leaves and their antioxidant activity”, Vietnam Journal of Science and Technology, Vol. 58, No. 4 (2020), pp. 411-418.

[12]. R. Li, Z. Ding, J. Ding “Chemical constituents from Eupatorium adenophorum”, Acta Botanica Yunnanica, Vol. 19, No. 2 (1997), pp. 196-200.

[13]. G. Schmeda-Hirschmann, A. Tapia, C. Theoduloz, J. Rodríguez, S. López, G. E. Feresin “Free radical scavengers and antioxidants from Tagetes mendocina”, Zeitschrift für Naturforschung, Vol. 59c (2004), pp. 345-353. DOI:



How to Cite

Tô, L., Vũ Ngọc Toán, Đồng Ngọc Phúc, Trần Xuân Trúc, Vũ Minh Trang, Trần Thị Thu Thủy, and Phan Minh Giang. “Structures of Phenolic Compounds Isolated from Eupatorium Adenophorum”. Journal of Military Science and Technology, vol. 85, Feb. 2023, pp. 59-64, doi:10.54939/1859-1043.j.mst.85.2023.59-64.



Research Articles