Study on evaluation the incompatibility of modafinil with some excipients and solubility and dissolution rate

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Authors

  • Le Hong Minh (Corresponding Author) Institute of New Technology, Academy of Military Science and Technology
  • Nguyen Minh Tri Institute of New Technology, Academy of Military Science and Technology
  • Vu Ngoc Toan Institute of New Technology, Academy of Military Science and Technology
  • To Phuong Linh Institute of New Technology, Academy of Military Science and Technology
  • Nguyen Thi Thu Huong Institute of New Technology, Academy of Military Science and Technology

DOI:

https://doi.org/10.54939/1859-1043.j.mst.89.2023.73-80

Keywords:

Modafinil; Smart drug; Nootropic drug; USP.

Abstract

Modafinil has been used as ”smart drugs”, was manufactured by Cephalon Pharmaceutical Company, Pennsylvania. It was approved by the FDA in 1998 to treat narcolepsy. In previous studies, modafinil was easily synthesized in three stages via the Bunte salt intermediate, yield above 70%. The results of quality assessment of the product after synthesis met the requirements of USP 41. This article presented the results of research to evaluate the incompatibility of modafinil active ingredient with some excipients and solubility, dissolution rate of them, as the basis for preparation of modafinil in tablet form.

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Published

25-08-2023

How to Cite

Lê, M., Nguyễn Minh Trí, Vũ Ngọc Toán, Tô Phương Linh, and Nguyễn Thị Thu Hương. “Study on Evaluation the Incompatibility of Modafinil With Some Excipients and Solubility and Dissolution Rate”. Journal of Military Science and Technology, vol. 89, no. 89, Aug. 2023, pp. 73-80, doi:10.54939/1859-1043.j.mst.89.2023.73-80.

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